Macrophages Sequester Clofazimine in an Intracellular Liquid Crystal-Like Supramolecular Organization
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چکیده
منابع مشابه
Macrophages Sequester Clofazimine in an Intracellular Liquid Crystal-Like Supramolecular Organization
Clofazimine is a poorly-soluble but orally-bioavailable small molecule drug that massively accumulates in macrophages when administered over prolonged periods of time. To determine whether crystal-like drug inclusions (CLDIs) that form in subcellular spaces correspond to pure clofazimine crystals, macrophages of clofazimine-fed mice were elicited with an intraperitoneal thioglycollate injection...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0047494